Pharmaceutical

Granulometry for compacting tablets: a practical guide for 3 to 10 t presses

Recommended granulometry for 3 and 10 ton presses (D50/D90 and fineness control)

Granulometry for compacting tablets: 3 t and 10 t presses

The PSD (Particle Size Distribution) determines whether a powder flows well and compacts without problems. In this guide you will see the size ranges (in microns, µm) recommended for 3-ton presses and 10 tons, and how to prepare them with powder mixers and oscillating crushers.

What do D10, D50 and D90 mean?

  • D10: : 10 % of the particles is minor that this size.

  • D50 (medium): 50 % of the particles is minor and the 50 % elderly.

  • D90: 90 % of the particles is minor that this size (controls the thick “tail”).


Recommended granulometry per press

PressUseful window (most dust)Aim D50Limit D90Fine <150 µmExplanation
3 tons150–450 µm200–300 µm≤ 600–800 µm≤ 2–3 %Somewhat finer powder (without excess fines) for good compaction with less available force.
10 tons150–500 µm250–400 µm≤ 800–900 µm≤ 2–3 %Slightly coarser particles are allowed due to the increased strength; keep fines under control.

Useful shortcuts with sieves (approx.): 100 mesh ≈ 149 µm · 60 mesh ≈ 250 µm · 35 mesh ≈ 500 µm.


How to get to that PSD with your teams

1) Powder mixers (ribbon, V, double cone)

  • Aim: homogeneity + good flow + compressibility.

  • Recommended sequence: base → diluents/agglomerates → lubricant at the end (short mix) so as not to “soften” too much.

  • Checkpoint: finite <150 µm ≤ 2–3 % to avoid poor flow, weight variation and capping/lamination.

2) Oscillating crushers / granulators

  • Key use: give final shape to the distribution → the mesh selected sets the D90.

  • If D90 is passed, reduces mesh and sieve again; if there are many fines, mix with a 150–500 µm fraction or dust.

3) Tablet presses (3 t and 10 t)

 

  • 3 t: will appreciate a D50 200–300 µm and D90 ≤ 600–800 µm.

  • 10 t: admits D50 250–400 µm and D90 ≤ 800–900 µm, always with few fine ones.

Quick process checklist

 

  • Flow: Check the hopper/auger; if you see “bridges,” there are too many fines or an unfavorable shape.

  • Lubricant (e.g. magnesium stearate): 0.5–1 % (up to 2 %) and short mix at the end.

  • Process humidity: controls to avoid “caking” and loss of hardness.

  • Validation: Make 2 batches per press with D50 slightly different (e.g., 220 vs. 280 µm at 3 t) and measures weight, hardness, friability and defects (capping).

 

Brief FAQ

Why not use “very fine” powder?
Because flows worse, generates weight variation and increases the risk of capping/lamination.

Can I use coarse grain with 10t?
Yes, within control: D90 ≤ 800–900 µm and very low fines.

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